Estradiol/nomegestrol acetate

Estradiol/nomegestrol acetate (E2/NOMAC), sold under the brand names Naemis and Zoely among others, is a fixed-dose combination product of estradiol, an estrogen, and nomegestrol acetate, a progestogen, which is used in menopausal hormone therapy in and as a birth control pill to prevent pregnancy in women.[1] It is taken by mouth.

Estradiol / nomegestrol acetate
Estradiol (top) and
nomegestrol acetate (bottom)
Combination of
EstradiolEstrogen
Nomegestrol acetateProgestogen
Clinical data
Trade namesNaemis, Zoely
Other namesE2/NOMAC
AHFS/Drugs.comUK Drug Information
Routes of
administration		By mouth
Drug classEstrogen; Progestogen
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
KEGG

Research

Estradiol-containing birth control pills like E2/NOMAC may have a lower risk of venous thromboembolism than birth control pills containing ethinylestradiol.[2] This is being studied in the case of E2/NOMAC.[2]

See also

References
  1. Yang LP, Plosker GL (October 2012). "Nomegestrol acetate/estradiol: in oral contraception". Drugs. 72 (14): 1917–28. doi:10.2165/11208180-000000000-00000. PMID 22950535. S2CID 44335732.
  2. Douxfils J, Morimont L, Bouvy C (October 2020). "Oral Contraceptives and Venous Thromboembolism: Focus on Testing that May Enable Prediction and Assessment of the Risk". Semin Thromb Hemost. doi:10.1055/s-0040-1714140. PMID 33080636.
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