Hatchet ribozyme
The hatchet ribozyme is an RNA structure that catalyzes its own cleavage at a specific site. In other words, it is a self-cleaving ribozyme. Hatchet ribozymes were discovered by a bioinformatics strategy [1] as RNAs Associated with Genes Associated with Twister and Hammerhead ribozymes, or RAGATH.
| Hatchet | |
|---|---|
 Consensus secondary structure and sequence conservation of Hatchet ribozyme | |
| Identifiers | |
| Symbol | Hatchet |
| Rfam | RF02678 |
| Other data | |
| RNA type | Gene; Ribozyme |
| GO | GO:0003824 |
| SO | SO:0000374 |
| PDB structures | PDBe |
Subsequent biochemical analysis supports the conclusion of a ribozyme function, and determined further characteristics of the chemical reaction catalyzed by the ribozyme.[2]
References
- Weinberg Z, Kim PB, Chen TH, Li S, Harris KA, Lünse CE, Breaker RR (2015). "New classes of self-cleaving ribozymes revealed by comparative genomics analysis". Nat. Chem. Biol. 11 (8): 606–10. doi:10.1038/nchembio.1846. PMC 4509812. PMID 26167874.
- Li S, Lünse CE, Harris KA, Breaker RR (2015). "Biochemical analysis of hatchet self-cleaving ribozymes". RNA. 21 (11): 1845–51. doi:10.1261/rna.052522.115. PMC 4604424. PMID 26385510.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.