Methylchloroisothiazolinone

Methylchloroisothiazolinone, also referred to as MCI, is the organic compound with the formula S(C2HCl)C(O)N(CH3). It is a white solid that melts near room temperature. The compound is an isothiazolinone, a class of heterocycles used as biocides. MCI is often used in combination with methylisothiazolinone, a mixture known as Kathon. The isothiazolinones have attracted attention because they can cause contact dermatitis.[1] [2][3]

Methylchloroisothiazolinone
Names
IUPAC name
5-Chloro-2-methyl-1,2-thiazol-3(2H)-one
Other names
5-Chloro-2-methylisothiazol-3(2H)-one
5-Chloro-2-methyl-4-isothiazolin-3-one
Chloromethylisothiazolinone
Chloromethylisothiazolone
Methylchloroisothiazolinone
Methylchloroisothiazolone
CMI
CMIT
MCI
MCIT
Identifiers
3D model (JSmol)
1210149
ChEBI
ChemSpider
DrugBank
ECHA InfoCard 100.043.167
EC Number
  • 247-500-7
UNII
Properties
C4H4ClNOS
Molar mass 149.59 g·mol−1
Appearance white solid
Density 1.02 g/cm³
Melting point 52 °C (126 °F; 325 K)
Miscible
Hazards
GHS pictograms
GHS Signal word Danger
H300, H301, H301, H310, H311, H314, H317, H318, H330, H331, H335, H400, H410
P260, P261, P262, P264, P270, P271, P272, P273, P280, P284, P301+310, P301+330+331, P302+350, P302+352, P303+361+353, P304+340, P305+351+338, P310, P311, P312, P320, P321, P322, P330, P333+313
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

References
  1. Silva, Vânia; Silva, Cátia; Soares, Pedro; Garrido, E. Manuela; Borges, Fernanda; Garrido, Jorge (2020). "Isothiazolinone Biocides: Chemistry, Biological, and Toxicity Profiles". Molecules. 25 (4): 991. doi:10.3390/molecules25040991. PMC 7070760. PMID 32102175.
  2. Reinhard; et al. (2001). "Preservation of products with MCI/MI in Switzerland". Contact Dermatitis. 45 (5): 257–264. doi:10.1034/j.1600-0536.2001.450501.x. PMID 11722483. S2CID 21296570.
  3. Knudsen BB, Menne T (1990). "Kathon CG--a new contact sensitizing preservative". Ugeskrift for Lægerer. 152 (10): 656–657. PMID 2321281.
  • Record in the Household Products Database of NLM

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