Ruhugu virus

Ruhugu virus is the second of only three members of the genus Rubivirus. It was discovered in 2020 and belongs to the family of Matonaviridae, a single-stranded RNA of positive polarity which is enclosed by an icosahedral capsid.

Ruhugu virus
Virus classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Kitrinoviricota
Class: Alsuviricetes
Order: Hepelivirales
Family: Matonaviridae
Genus: Rubivirus
Species:
Ruhugu virus

Etymology

Ruhugu virus was found in healthy Cyclops roundleaf bats in Kibale National Park, Uganda and was named after the Ruteete region of Uganda and the local word for bat.[1]

Structure

Ruhugu virus is identical in genome to Rubella virus and differs in only one amino acid in the protein it uses to get into host cells. [2]In the fusion protein of the virus and two putative T cell epitopes in the capsid protein of the ruhugu virus the amino acid sequences of four putative B cell epitopes are moderately to highly conserved, suggesting ruhugu viruses have a similar capacity for fusion with the host-cell membrane like rubella virus.[3]

References
  1. Gibbons, Ann (7 October 2020). "Newly discovered viruses suggest 'German measles' jumped from animals to humans". science. doi:10.1126/science.abf1520.
  2. Bennett, Andrew. "Relatives of rubella virus in diverse mammals". Nature. Nature. Retrieved 16 November 2020.
  3. Bennett, Andrew J.; Paskey, Adrian C.; Ebinger, Arnt; Pfaff, Florian; Priemer, Grit; Höper, Dirk; Breithaupt, Angele; Heuser, Elisa; Ulrich, Rainer G.; Kuhn, Jens H.; Bishop-Lilly, Kimberly A. (7 October 2020). "Relatives of rubella virus in diverse mammals". Nature: 1–5. doi:10.1038/s41586-020-2812-9. ISSN 1476-4687. PMID 33029010.


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