SB 203580

SB 203580[1]
Names
	IUPAC name 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
	Other names RWJ-64809;
Identifiers
CAS Number	152121-47-6 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL10 ;
ChemSpider	153453 ;
ECHA InfoCard	100.214.849
IUPHAR/BPS	5269;
PubChem CID	176155;
UNII	OU13V1EYWQ ;
CompTox Dashboard (EPA)	DTXSID2040577 ;
	InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) Key: CDMGBJANTYXAIV-UHFFFAOYSA-N ; InChI=1/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) Key: CDMGBJANTYXAIV-UHFFFAOYAY;
	SMILES CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F;
Properties
Chemical formula	C21H16FN3OS
Molar mass	377.43 g/mol
Appearance	White to off-white solid
Solubility in DMSO	50 mg/mL
Hazards
Main hazards	Xn
R-phrases (outdated)	R22 R41
S-phrases (outdated)	S26 S39
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27. At low concentrations, it does not inhibit JNK activity.

References

SB 203580 at Sigma-Aldrich

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[1] SB 203580 at Sigma-Aldrich